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In relation to mood disorders, several published case reports reported the association between ma-huang use and manic-like symptoms, such as psychomotor agitation, pressured speech, flight of ideas, suicidal ideation, irritability, aggressive and disorganized behavior, and reduced need for sleep [ 45 — 50 ].

Manic-like Best diet pills in sweden occurred both in patients with no previous psychiatric illness and in patients with a family history of bipolar perdiendo peso. These manic-like symptoms occurred when ma-huang was being assumed at the manufacturer recommended dosages, at doses exceeding the recommended amounts, or after dose escalation the exact dosages were not reported [ 45 — 50 ].

Following acute manic episodes, symptom remission was typically achieved with or without Best diet pills in sweden [ 45 — 50 ], although one patient reportedly developed long-lasting residual disturbances such as boundary control and obtrusive, loud speech [ 47 ]. Two case reports also detected the association between ma-huang use and Best diet pills in sweden mood [ 4445 ], with depressive symptoms occurring after 1 year of use [ 44 ] or after the first use [ 45 ] of the herb. Another case report described a woman with severe obsessive-compulsive disorder who was effectively treated with fluvoxamine and Eye Movement Desensitization and Reprocessing EMDR treatments but relapsed following the ingestion of a single capsule of an herbal product containing ma-huang used to facilitate weight loss [ 51 Best diet pills in sweden.

An additional relevant adverse psychiatric effect possibly related to ma-huang use is the onset of ephedrine addiction. Miller and Waite reported the case of a year-old male with no psychiatric comorbidity whose use of a dietary supplement containing ma-huang progressed to substance abuse and quite possibly substance dependence [ 52 ].

He progressively escalated the assumed dose to more than four times the recommended amount one capsule, two times per dayexhibiting symptoms of tolerance and withdrawal [ 52 ].

In a case series of seven patients with amphetamine-like abuse or dependence, two showed ephedrine abuse and three ephedrine dependence according to the DSM-IV diagnostic criteria [ 53 ]. The FDA reports of adverse events found five patients 8. Paullinia cupana guarana is a plant native to the Amazon region and is especially common in Brazil [ 55 ].

Guarana seeds contain a wide number of stimulant and psychoactive substances, including twice the amount of caffeine present in coffee Best diet pills in sweden and other xanthine alkaloids such as theobromine and theophylline [ 5556 ]. The plant is commonly used in soft drinks and energy drinks but its stimulant properties have made it a frequent ingredient in weight-loss compounds, with some evidence supporting its weight-loss effectiveness [ 47 — 49 ].

Due to the Best diet pills in sweden caffeine content of its seeds, excessive intake of guarana may cause symptoms of caffeine intoxication e. The World Health Organization-Adverse Drug Reactions WHO-ADR database reported guarana to be associated with cases of personality disorder, manic reaction, insomnia, somnolence, asthenia, fatigue, anxiety, and impaired concentration [ Best diet pills in sweden60 ].

Galduróz and Carlini [ 61 ] and Boozer et al. Pausinystalia yohimbe is a plant native to Central Africa [ 63 ]. The association between yohimbine, an alkaloid derived from the bark of the plant, and weight loss has been consistently reported [ 2363 — 66 ].

For example, Kucio et al. Yohimbine is an alpha2-adrenoceptor antagonist that produces sympathetic activation by increasing noradrenaline release and Best diet pills in sweden firing rate of neurons located in noradrenergic nuclei Adelgazar 20 kilos the central nervous system CNS Como adelgazar las llantitas de los lados 6768 ].

Consistently, increases in anxiety symptoms are the most commonly reported adverse psychiatric effects associated with yohimbine, both in healthy people [ 6970 ] and in psychiatric patients especially in those with preexistent anxiety disorders [ 71 — 76 ].

In healthy individuals, an intravenous dose of yohimbine 0. A significant decrease of cerebral blood flow, especially in the cortical regions, following yohimbine administration has also been observed [ 69 ]. Charney et al. Furthermore, Gurguis et al. The increase of anxiety symptoms after intravenous dose of yohimbine 0. In addition to anxiety, yohimbine has also been associated with other adverse psychiatric effects. Yohimbine has been reported to induce addictive drug seeking behaviour [ 77 ], objective and subjective withdrawal, and elevated craving in heroin-dependent patients [ 78 ].

Scherr et al. It is reported that, compared to placebo, oral administration of yohimbine 0. Finally, Price et al. Herb-drug interactions have become an important issue Best diet pills in sweden drug safety Best diet pills in sweden clinical practice, possibly resulting in drug toxicities, reduced pharmacological effects, and adverse drug reactions. In this section Dietas rapidas review the available evidence of interactions between HWLPs and psychiatric medications.

Two case reports suggest an interaction between ginseng and phenelzine [ 84 — 86 ]. A year-old woman described symptoms of headache and tremulousness when ginseng was added to her phenelzine therapy; three years later, whilst still taking phenelzine, she experienced similar symptoms upon ingesting ginseng capsules [ 8586 Best diet pills in sweden.

When the ginseng preparation was discontinued, she no longer experienced any therapeutic benefit of the phenelzine [ 84 ].

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An interaction between ginseng, vitamin B complex, and sertraline resulting in a reduction of therapeutic response has also been reported [ 24 ]. Ginseng contains a mixture of saponin glycosides called ginsenosides. It has been found that ginsenosides inhibit cyclic AMP phosphodiesterase [ 87 ]; this may account partly for ginseng interaction with monoamine oxidase inhibitors MAOIs such as phenelzine, although an exact delineation of the mechanism would require further study.

As written above, the predominant active component of ma-huang, that is, ephedrine, is a sympathomimetic agent with a chemical structure very similar to that of amphetamine [ 36 ]. It acts directly and indirectly at alpha- and beta-adrenergic receptors, potentially Best diet pills in sweden increased blood pressure and heart rate, relaxation of bronchial and gastrointestinal smooth muscle, CNS stimulation, and mydriasis [ 88 ].

When ma-huang is administered in combination with MAOIs, its sympathomimetic activity can reportedly increase the risk of hypertensive crisis [ 89 ]. However, it Best diet pills in sweden also possible that stopping the phenelzine suddenly contributed to inducing the side effects. Guarana extracts have high content of caffeine [ 5556 ], which is metabolized by CYP1A2 a protein of the cytochrome P family of isoenzymes responsible for the biotransformation of several drugs [ 5890 ].

When used concomitantly, caffeine and certain psychiatric medications e. One study has also reported that abruptly ceasing Best diet pills in sweden daily consumption of caffeine may result in a significant increase in lithium blood levels [ 95 ]. However, no studies have reported interactions between guarana and psychiatric medications so far. Pharmacodynamic and pharmacokinetic interactions between yohimbine and certain tricyclic antidepressants i.

It has been reported that yohimbine toxicity is potentiated by tricyclic antidepressants and phenothiazines in mice [ 99 ]. Lacomblez et al. In addition, one preclinical [ ] and one clinical study [ 90 ] suggested that concomitant administration of yohimbine may lead to more rapid rates of psychiatric effects of selective serotonin reuptake inhibitors SSRIs by shortening the delay in obtaining tonic activation of the postsynaptic 5-HT1a receptors through its alpha2-antagonist activity.

Best diet pills in sweden supplements of Plantago psyllium psyllium may contribute to a Best diet pills in sweden lipid, glucose, and insulin metabolism and are extensively used for weight-loss purposes [ ]. Two studies to date have reported interactions between psyllium and psychiatric drugs: Fong et al. Rhodiola rosea Rhodiola has a long history as a valuable medicinal plant having appeared in the Materia Medica of a number of European countries [ ].

Rhodiola use has been suggested to reduce food intake [ 4748 ] and to inhibit angiotensin converting enzyme ACEresulting in a possible positive effect on metabolism [ ]. Rhodiola can modulate hypothalamic-pituitary-adrenal HPA axis activity as well as that of several Best diet pills in sweden [ ]. Maniscalco et al. Seed extracts of Trigonella foenum-graecum fenugreek have long been used as an herbal medicine for treating metabolic and nutritive dysfunctions and have been shown to selectively reduce spontaneous fat intake in overweight subjects [ ].

To the best of our knowledge, this is the first study aimed at specifically reviewing the adverse psychiatric effects associated with HWLPs. Results indicate that a range of adverse psychiatric events could theoretically result from the use of HWLPs. Though the evidence of psychiatric symptoms associated with HWLPs may collectively look impressive, the Adelgazar 40 kilos provided in the reviewed studies is often insufficient for making reliable inferences about causality; therefore, in some cases it may be unnecessarily alarmist to accept a cause-effect relationship between HWLPs and psychiatric symptoms.

In addition to the reviewed evidence i. Herbal products, in fact, undergo reduced quality control and safety testing in comparison to medications [ 18 ].

For example, adulterants that have been identified in HWLPs include sibutramine [ ], fenfluramine [ ], or thyroid hormones [], which are molecules with well-known potential deleterious effects on CNS, mental status, and behaviour [ — ]. For example, Valeriana officinalis Best diet pills in swedenPassiflora incarnata purple passionflowerMelissa officinalis lemon balmand Hypericum perforatum St.

Even though extracts of these herbs have never been shown to improve obesity or metabolism, they are often sold on the Internet with the purpose of calming stress-induced hunger and eating behaviours related to nervousness [ 19— ].

People, in fact, are becoming increasingly aware of the link between mood, poor sleep quality, and obesity [ 19,]. In an attempt to address mood and sleep disturbances, consumers may use products containing extracts of these plants, considering this intervention to be a relevant part of their weight-loss program [ 19— ] and subsequently increasing their risk of Best diet pills in sweden psychiatric effects.

It is possible that obesity per se may lead to higher vulnerability to the development of psychiatric disorders [ ], meaning that obese individuals may represent a psychiatrically at-risk population and the use of HWLPs with potential adverse psychiatric effects among them may be of particular concern. In conclusion, adverse psychiatric events and interactions with psychiatric drugs are reported for a number of herbal products commonly used for reducing body weight.

Physicians, psychiatrists, and other health and mental health professionals should remind patients that i diet, exercise, and healthy lifestyle are the safest and most effective weight-loss strategies and ii the HWLPs, though potentially effective for weight loss, may have a heterogeneous nature and may Best diet pills in sweden associated with psychiatric risks.

It is also true that certain HWLPs may exert beneficial effects on CNS and on certain psychiatric conditions [ ], but this analysis was not included as a part of the objective of the present review.

Future studies should include safety mental health measures in relation to this growing pattern Best diet pills in sweden substance use. The authors declare that there is no conflict of interests regarding the publication of this paper.

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This paper arises from collaborative activities and staff exchanges among collaborating institutions funded by the European Commission. Saverio Bersani et al. This is an open access article distributed Best diet pills in sweden the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly Best diet pills in sweden.

Journal overview. Special Issues. Academic Editor: Adair Santos. Received 28 May Accepted 02 Aug Published 17 Sep Abstract Obesity and overeating are among the most prevalent health concerns worldwide and individuals are increasingly using performance and image-enhancing drugs PIEDs as an easy and fast way to control their weight.

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Methods In the following sections, we review the evidence of HWLPs adverse effects relevant to psychiatric conditions. Ephedra sinica Ephedra sinica ma-huang is an evergreen shrub native to Central Asia, whose dried parts have been used for thousands of years in the traditional Chinese medicine for the treatment of various respiratory conditions [ 35 ].

Paullinia cupana Paullinia cupana guarana is a plant native to the Amazon region and is especially common in Brazil [ 55 ]. Pausinystalia yohimbe Pausinystalia yohimbe is a plant native to Central Africa [ 63 ].

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While the use of ICDs seems to have stabilized over the past decades, the market of NPSs has significantly grown, representing an unprecedented challenge in the field of global health from medical, social, cultural, legal, and political perspectives [ Best diet pills in sweden — 11 ].

The term PIED is an umbrella term used to describe a variety of substances taken to enhance human abilities [ 14 ]. Obesity and overeating are becoming one of the most prevalent health concerns among all populations and age groups worldwide, resulting in a significant increase in mortality and morbidity [ 1516 ].

Though diet, exercise, and healthy lifestyle are the mainstays of obesity management [ 1516 ], the use of PIEDs is increasing as it is viewed as an easier alternative to controlling weight [ 17 — 20 ]. In addition, the use of PIEDs is also increasing in nonobese and nonovereating populations [ 12 ]. Among the different PIEDs, herbal weight-loss products HWLPs often attract users due to their health claims, Best diet pills in sweden safety, easy availability from specialised shops and the Internet, affordable price, extensive marketing, and the perceived lack of need for professional oversight [ 17 — 20 ].

Certain HWLPs may have a significant antiobesity effect Best diet pills in sweden 22 ], with some studies reporting potential somatic adverse effects associated with their use [ 181923 ]. Associations between the use of HWLPs and onset or exacerbation of psychiatric los adelgazar brazos sobrante piel Reducir, including mood disturbances, anxiety, psychosis, addiction, and delirium have also been reported reviewed below.

However, the relationship between HWLPs and psychiatric disturbances has been relatively unstudied so far, and there is a lack of structured and consistent research on the topic. The information provided in the studies reporting theoretical associations between HWLPs and psychiatric Best diet pills in sweden is often i based on single-case reports and ii insufficient for making reliable inferences about causality.

Therefore, rather than drawing conclusions, the purpose of this review is to aggregate and report available data, to heighten awareness of the possible relationship between HWLPs and adverse Best diet pills in sweden effects, and to encourage future studies to include mental health measures in relation to this rapidly growing pattern of substance use.

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In the following sections, we review the evidence of HWLPs adverse effects relevant to psychiatric conditions. In Section 3 we review the evidence of adverse psychiatric effects of HWLPs that are attributable to Best diet pills in sweden intrinsic toxicity of the herbs; in Section 4 we review the evidence of interactions between HWLPs and psychiatric medications. Our review Best diet pills in sweden started with MedLine searches to identify herbal products with weight-loss properties.

We then performed more specific MedLine searches to explore adverse psychiatric effects on humans and interactions with psychiatric medications for each herbal product with documented weight-loss properties.

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It is often used for weight-loss purposes, as it has been suggested to improve glucose tolerance, reduce LDL plasma levels, and contribute to global inhibition of body weight gain [ 19Best diet pills in sweden ]. There is evidence of ginseng modulatory activity on the noradrenergic, dopaminergic, Best diet pills in sweden, cholinergic, and endorphin systems [ 26 — 28 ], and there have been several reports of psychiatric symptoms associated with the use of ginseng both in healthy people and in patients previously affected by psychiatric disorders reviewed below.

In the World Health Organization WHO Collaborating Centre for International Drug Monitoring Database and UK Medicines Control Agency reports of adverse Best diet pills in sweden, ginseng monopreparations have been associated with cases of insomnia, nervousness, manic reaction, amnesia, somnolence, anorexia, anxiety, emotional lability, hallucination, sleep disorder, confusion, depression, and abnormal thinking [ 24 ]. Some studies have also reported associations in the exacerbation or Best diet pills in sweden of psychiatric symptoms with ginseng use in patients affected by psychiatric disorders.

Two case reports by Gonzalez-Seijo et al. Gonzalez-Seijo et al. Best diet pills in sweden is not known, however, if ginseng per se may have induced the manic episode or, rather, the manic episode was precipitated by amitriptyline or lithium withdrawal [ 32 ].

A third report described that five inpatients with schizophrenia became irritable, uncooperative, and overactive with disturbed sleep after smoking ginseng-containing cigarettes Best diet pills in sweden that, after cessation of smoking these cigarettes, these behavioural symptoms improved [ 34 ].

Ephedra sinica ma-huang is an evergreen shrub native to Central Asia, whose dried parts have been used for thousands of years in the traditional Chinese medicine for the treatment of various respiratory conditions [ 35 ]. Its main biologically active component is the alkaloid ephedrine, a sympathomimetic agent [ 36 ]. The chemical structure of ephedrine is very similar to that of amphetamine; in fact, amphetamines have been originally synthesized as a substitute for ephedrine [ 36 ]. Ina Danish physician first noted unintentional weight loss in a patient taking ephedrine-containing pills for asthma [ 37 ].

Subsequently, ma-huang became one of the most commonly used herbs for weight loss [ 38 ]. A meta-analysis reported that ma-huang promoted modest short-term weight loss approximately 0. This effect is said to be mainly due to a sympathomimetic stimulation of thermogenesis in skeletal muscles [ 3740 ]. Ephedrine can rapidly pass Best diet pills in sweden the blood-brain barrier [ 35 ] and can stimulate short-term release of dopamine and norepinephrine, as well as long-term depletion of monoamine [ 41 ].

Ma-huang use Adelgazar 20 kilos been associated with several psychiatric adverse effects reviewed below. A meta-analysis of 50 trials on the use of ma-huang in the treatment of obesity yielded estimates of 2. In a review of 1, previously unpublished Food and Drug Administration FDA reports of Best diet pills in sweden events concerning ma-huang, the use of the herb was associated with 57 serious psychiatric episodes [ 41 ].

Thirty-two Other common adverse events not mutually exclusive were severe depression Most patients Both patients reportedly used ephedrine to treat respiratory diseases and had no previous mental illnesses [ 42 ]. Additional cases of ephedrine-induced psychosis have more recently been described [ 43 — 46 ].

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In relation to mood disorders, several published case reports reported the association between ma-huang use and manic-like symptoms, such as psychomotor agitation, pressured speech, flight of ideas, suicidal ideation, irritability, aggressive and disorganized behavior, and reduced need for sleep [ 45 — 50 ].

Manic-like symptoms occurred both in patients with no previous psychiatric illness and in patients with a family history of bipolar disorder. These manic-like symptoms occurred when ma-huang was being assumed at the manufacturer recommended dosages, at doses exceeding the recommended amounts, or after dose escalation the exact dosages were Best diet pills in sweden reported [ 45 — 50 ]. Following acute manic episodes, symptom remission was typically achieved with or without pharmacotherapy [ 45 — 50 ], although one patient reportedly developed long-lasting residual disturbances such as boundary control and obtrusive, loud speech [ 47 ].

Two case reports also detected the association between ma-huang use and depressed mood [ 4445 ], with depressive symptoms occurring after 1 year of use [ 44 ] or after the first use [ 45 ] of the herb. Another case report described a woman with severe obsessive-compulsive disorder who was effectively treated with fluvoxamine and Eye Movement Desensitization and Reprocessing EMDR treatments but relapsed following the ingestion of a single capsule of an herbal product containing ma-huang used to facilitate weight loss [ 51 ].

An additional La buena dieta adverse psychiatric effect possibly related to ma-huang use is the onset of ephedrine addiction. Miller and Waite reported the case of a year-old male with no psychiatric comorbidity whose use of a dietary supplement containing ma-huang progressed to substance abuse and quite possibly substance dependence [ 52 ].

He progressively escalated the assumed dose to more than four times the recommended amount one capsule, two times per dayexhibiting symptoms of tolerance and withdrawal [ 52 ]. In a case series of seven patients with amphetamine-like abuse or dependence, two showed ephedrine abuse and three ephedrine dependence according to the DSM-IV diagnostic La buena dieta [ 53 ]. The FDA reports of adverse events found five patients 8.

Paullinia cupana guarana is a plant native to the Amazon region and is especially common in Brazil [ 55 ]. Guarana seeds contain a wide number of stimulant Best diet pills in sweden psychoactive substances, including Best diet pills in sweden the amount of caffeine present in coffee beans and other xanthine alkaloids such as theobromine and theophylline [ 5556 ]. The plant is commonly used in Best diet pills in sweden drinks and energy drinks but its stimulant properties have made it a frequent ingredient in Best diet pills in sweden compounds, with some Best diet pills in sweden supporting its weight-loss effectiveness [ 47 — 49 ].

Due to the high Best diet pills in sweden content of its seeds, excessive intake of guarana may cause symptoms of caffeine intoxication e.

The World Health Organization-Adverse Drug Reactions WHO-ADR database reported guarana to be associated with cases of personality disorder, manic reaction, insomnia, somnolence, asthenia, fatigue, anxiety, and impaired concentration [ 2360 ].

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Galduróz and Carlini [ 61 ] and Boozer et al. Pausinystalia yohimbe is a plant native to Central Africa [ 63 ]. The association between yohimbine, an alkaloid derived from the bark of the plant, and weight loss has been consistently reported [ 2363 — 66 ].

For Best diet pills in sweden, Kucio et al. Yohimbine is an alpha2-adrenoceptor antagonist that produces sympathetic activation by increasing noradrenaline release and the firing rate of neurons located in noradrenergic nuclei of the central nervous system CNS [ 6768 ]. Consistently, increases in anxiety symptoms are the most commonly reported adverse psychiatric effects associated with yohimbine, both in healthy people [ 6970 ] and in psychiatric patients especially in those with preexistent anxiety disorders [ 71 — Best diet pills in sweden ].

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In healthy individuals, an intravenous dose of yohimbine 0. A significant decrease of cerebral blood flow, especially in the cortical regions, following yohimbine administration has also been observed [ 69 ]. Charney et al. Furthermore, Gurguis et al. The increase of anxiety symptoms Best diet pills in sweden intravenous dose of yohimbine 0. In addition to anxiety, yohimbine has also been associated with other adverse psychiatric effects. Yohimbine has been reported to induce addictive drug seeking behaviour [ 77 ], objective and subjective withdrawal, and elevated craving in heroin-dependent patients [ 78 ].

Scherr et al. It is reported that, compared to placebo, oral administration of yohimbine 0. Finally, Price et al. Herb-drug interactions have become an important issue in drug safety and clinical practice, possibly resulting in drug toxicities, reduced pharmacological effects, and adverse drug reactions. In this section we review the available evidence of interactions between HWLPs and psychiatric medications. Two case reports suggest an interaction between ginseng and phenelzine [ 84 — 86 ].

A year-old woman described symptoms of headache and tremulousness when ginseng Best diet pills in sweden added to her phenelzine therapy; three years later, whilst still taking phenelzine, she experienced similar symptoms upon ingesting ginseng capsules [ 8586 ]. Best diet pills in sweden the ginseng preparation was discontinued, she no longer experienced any therapeutic benefit of the phenelzine [ 84 ].

An interaction between ginseng, vitamin B Best diet pills in sweden, and sertraline resulting in Adelgazar 72 kilos reduction of therapeutic response has also been reported [ 24 ]. Ginseng contains a mixture of saponin Best diet pills in sweden called ginsenosides.

It has been found that ginsenosides inhibit cyclic AMP phosphodiesterase [ 87 ]; this may account partly for ginseng interaction with monoamine oxidase inhibitors MAOIs such as phenelzine, although an exact delineation of the mechanism would require further study.

As written above, the predominant active component of ma-huang, that is, ephedrine, is a sympathomimetic agent with Best diet pills in sweden chemical structure very similar to that of amphetamine [ 36 ]. It acts directly and indirectly at alpha- and beta-adrenergic receptors, potentially causing increased blood pressure and heart rate, relaxation of bronchial and gastrointestinal smooth muscle, CNS stimulation, and mydriasis [ 88 ].

When ma-huang is administered in combination with MAOIs, its sympathomimetic activity can reportedly increase the risk of hypertensive crisis [ 89 ]. However, it is also possible that stopping the phenelzine suddenly contributed to inducing the side effects. Guarana extracts have high content of caffeine [ 5556 ], which is metabolized by CYP1A2 a protein of the cytochrome P family of isoenzymes responsible for the biotransformation of several drugs [ 5890 ]. When used concomitantly, caffeine and certain psychiatric medications e.

One study has also reported that abruptly ceasing the daily consumption Adelgazar comiendo muy poco caffeine may result in a significant increase in lithium blood levels [ 95 ]. However, no studies have reported interactions between guarana and psychiatric medications so far.

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Pharmacodynamic and pharmacokinetic interactions between yohimbine and certain tricyclic antidepressants i. It has been reported that yohimbine toxicity is potentiated by tricyclic antidepressants and phenothiazines in mice [ 99 ].

Lacomblez et al. In addition, one preclinical [ ] and one clinical study Best diet pills in sweden 90 ] suggested that concomitant administration of yohimbine may lead to more rapid rates of psychiatric effects of selective serotonin reuptake inhibitors SSRIs by shortening the delay in obtaining tonic activation of the postsynaptic 5-HT1a receptors through its alpha2-antagonist activity. Fibre supplements of Plantago psyllium psyllium may contribute to a salutary lipid, glucose, and insulin metabolism and are extensively used for weight-loss purposes [ ].

Two Adelgazar 40 kilos to date have reported interactions between psyllium and psychiatric drugs: Fong et al. Rhodiola rosea Rhodiola has a long history as a valuable medicinal plant having appeared in the Materia Best diet pills in sweden of a number of European countries [ ].

Rhodiola use has been suggested to reduce food intake [ 4748 ] and to inhibit angiotensin converting enzyme Best diet pills in swedenresulting in a possible positive effect on metabolism [ ].

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